이름
김승균
(Seung-Kyoon Kim)
전공
후성유전학
연락처
연구실
환경관리동 102-3호
경력
2022.03 ~ 현재까지: 충남대학교, 생명정보융합학과, 조교수 2020.01 ~ 2022.02: 포항공과대학교 (POSTECH), 생명과학과, 연구조교수 2014.06 ~ 2020.01: UT Southwestern Medical Center at Dallas, US, 뇌과학과, Postdoc 및 Research Scientist 2011.08 ~ 2014.05: 한국과학기술원 (KAIST), 생명과학과, Postdoc
관심분야
후성유전학 (Epigenetics/ Chromatin Biology)은 다양한 외부변화 및 자극에 의해 DNA 염기서열의 변화 없이 유전체 상에 발생하는 다양한 화학적 변화에 따른 유전자 발현 조절과 전사 후 조절 변화를 일으키는 기전을 이해하는 학문입니다. 또한 이러한 후성유전적 변화의 인과관계에 따른 정상적인 생물학적 경로 및 질병을 유발하는 다양한 기전을 이해하는 학문입니다. 본 연구실에서는 연구 목적에 따라 embryonic stem cells, induced pluripotent stem cells (iPSCs), primary cultured neurons, mouse disease models 등의 동물 시스템에서 다양한 분자·생화학적, 전유전체적 (Transcriptome 및 Epigenome), 전단백체적 (Mass-spec 기반 분석) 및 동물행동학적 분석법과 같은 다학제적인 접근법들을 사용한 포괄적인 분석을 통해 중요한 생명과학적 질문을 해결해 갑니다.
연구업적 (*대표업적)
홈페이지 참조
14. Seung-Kyoon Kim* (Corresponding author*), Lentiviral-based RNAi System for Efficient Depletion of Enhancer RNA
in Neurons. Methods Mol Biol., 2023 In press.
*13. V Gorbovytska+, Seung-Kyoon Kim+, F Kuybu, M Götze, D Um, K Kang, A Pittroff, L-M Schneider, A Leitner, Tae-Kyung
Kim*, Claus-Dieter Kuhn* (+Co-first author), Enhancer RNAs harness multivalent interactions to detach NELF from
paused Pol II. Nat Commun., 2022 May 4;13(1):2429
12. S Han, H Lee, A J Lee, Seung-Kyoon Kim, I Jung, G Y Koh, T-K Kim, Daeyoup Lee*, CHD4 conceals aberrant CTCF-
binding sites at TAD interiors by regulating chromatin accessibility in mESCs. Mol Cells, 2021 Nov 12; 44(11): 805-829
*11. Seung-Kyoon Kim+, X Liu+, J Park, D Um, G Kilaru, C-M Chiang, M Kang, K M Huber, Keunsoo Kang*, Tae-Kyung Kim*
(+Co-first author), Functional coordination of BET family proteins underlies altered transcription associated with
memory impairment in Fragile X syndrome. Science Adv., 2021 May 19; 7(21): eabf7346.
*10. Seung-Kyoon Kim, Tae-Kyung Kim, New Molecular Insights into the Excitation-Transcription Coupling.
Neuron, 2018 May 2; 98(3): 453 - 456 [Preview].
9. K Schaukowitch, A Reese, Seung-Kyoon Kim, G Kilaru, J-Y Joo, E Kavalali, Tae-Kyung Kim*, An Intrinsic Transcriptional
Program Underlying Synaptic Scaling during Activity Suppression. Cell Rep., 2017 Feb 7; 18(6): 1512-1526.
8. K‐M Han, Seung‐Kyoon Kim, D Kim, J‐Y Choi, I Im, K‐S Hwang, C‐H Kim, B H Lee, H‐W Yoo, Yong‐Mahn Han*,
Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs. Stem Cells, 2015 May;
33(5): 1447-1455.
*7. Seung-Kyoon Kim+, H Lee+, K Han, S C Kim, Y Choi, S-W Park, G Bak, Y Lee, J K Choi, T-K Kim, Yong-Mahn Han*,
Daeyoup Lee* (+Co-first author), SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization
mechanism that blocks let-7 biogenesis in human ESCs. Cell Stem Cell, 2014 Dec; 15; 735-749.
[See the Preview: Andrew P. Feinberg (2014) The Nucleolus gets the silent treatment. Cell Stem Cell 15, 675-676]
[This paper was highlighted as front cover paper on the journal]
[Best 100 National R&D Achievements (2015) from Ministry of Science, ICT and Future Planning]
[The Top 5 Achievements of Research and News in Life Science Division from BRIC]
[KAIST Top 10 representative researches Award]
*6. Seung-Kyoon Kim+, Inkyung Jung+, H Lee, K Kang, M Kim, K Jeong, C S Kwon, Y-M Han, Y S Kim, Dongsup Kim,
Daeyoup Lee* (+Co-first author), Human histone H3K79 methyltransferase DOT1L protein binds actively transcribing
RNA polymerase II to regulate gene expression. J Biol Chem., 2012 Nov; 16; 287 (47): 39698-39709.
*5. Inkyung Jung+, Seung-Kyoon Kim+, Mirang Kim+, Y-M Han, Y S Kim, Dongsup Kim*, Daeyoup Lee* (+Co-first author),
H2B mono-ubiquitylation is a 5’-enriched active transcription mark and correlates with exon-intron structure in
human cells. Genome Res., 2012 Jun; 22 (6): 1026-1035.
*4. Seung-Kyoon Kim, H-R Jang, J-H Kim, M Kim, S-M Noh, K-S Song, G H Kang, H J Kim, S-Y Kim, H-S Yoo, Yong Sung
Kim*, CpG methylation in exon 1 of transcription factor 4 increases with age in normal gastric mucosa and is
associated with gene silencing in intestinal-type gastric cancers. Carcinogenesis, 2008 Aug; 29: 1623-1631.
*3. Seung-Kyoon Kim, H-R Jang, J-H Kim, S-M Noh, K-S Song, M Kim, S-Y Kim, Y-I Yeom, N-S Kim, H-S Yoo, Yong Sung
Kim*, The epigenetic silencing of LIMS2 in gastric cancer and its inhibitory effect on cell migration. Biochem Biophys
Res Commun., 2006 Oct; 27; 349 (3): 1032-1040.
[This paper was highlighted as front cover paper on the journal]
2. HS Song, YH Park, Seung-Kyoon Kim, YK Moon, DW Kim, KY Moon*, Downregulatory Effect of Extracts from Mistletoe
(Viscum album) and Pueraria Root (Pueraria radix) on Cellular NF-B Activation and Their Antioxidant Activity.
J. of Korean Soc Food Sci Nutr., 2004 Nov; 33; 1594-1600.
1. HS Song, YJ Lee, Seung-Kyoon Kim, YK Moon, DW Kim, YS Kim, KY Moon*, Downregulatory Effect of AGI-1120
(-Glucosidase Inhibitor) and Chaga Mushroom (Inonotus obliquus) on Cellular NF-B Activation and Their
Antioxidant Activity. Kor. J. Pharmacogn., 2004 Feb; 35; 92-97.